QUÍMICA FÍSICA
DEPARTAMENTO
![Foto de Eduardo Carlos](/img/nophoto.png)
Eduardo Carlos
Salido Ruiz
Publicaciones en las que colabora con Eduardo Carlos Salido Ruiz (28)
2024
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Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine:glyoxylate aminotransferase variants
FEBS Letters, Vol. 598, Núm. 4, pp. 485-499
2023
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Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease-associated NQO1 enzyme*
FEBS Journal, Vol. 290, Núm. 7, pp. 1855-1873
2022
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Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity‐Making Mutations
Antioxidants, Vol. 11, Núm. 6
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Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations
Archives of Biochemistry and Biophysics, Vol. 729
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Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation
Frontiers in Molecular Biosciences, Vol. 9
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New salicylic acid derivatives, double inhibitors of glycolate oxidase and lactate dehydrogenase, as effective agents decreasing oxalate production
European Journal of Medicinal Chemistry, Vol. 237
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Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants
Molecules (Basel, Switzerland), Vol. 27, Núm. 24
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Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1
Journal of Personalized Medicine, Vol. 12, Núm. 5
2021
2020
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Naturally-occurring rare mutations cause mild to catastrophic effects in the multifunctional and cancer-associated NQO1 protein
Journal of Personalized Medicine, Vol. 10, Núm. 4, pp. 1-31
2019
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A dynamic core in human NQO1 controls the functional and stability effects of ligand binding and their communication across the enzyme dimer
Biomolecules, Vol. 9, Núm. 11
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Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses
Human Molecular Genetics, Vol. 28, Núm. 1, pp. 1-15
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Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I
Advances in Protein Chemistry and Structural Biology (Academic Press Inc.), pp. 119-152
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Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1
Nucleic Acid Therapeutics, Vol. 29, Núm. 2, pp. 104-113
2018
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Evolutionary divergent suppressor mutations in conformational diseases
Genes, Vol. 9, Núm. 7
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Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer
Handbook of Experimental Pharmacology (Springer New York LLC), pp. 155-190
2017
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Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution
Human Molecular Genetics, Vol. 26, Núm. 18, pp. 3531-3544
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Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism
Scientific Reports, Vol. 7
2016
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Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1: New insights into between-species divergence in glyoxylate metabolism
Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1864, Núm. 9, pp. 1195-1205
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Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands
Scientific Reports, Vol. 6