PARASITOLOGÍA
Departamento
London School of Hygiene & Tropical Medicine
Londres, Reino UnidoPublicaciones en colaboración con investigadores/as de London School of Hygiene & Tropical Medicine (18)
2023
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Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice
PLoS Pathogens, Vol. 19, Núm. 11 November
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Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose
Journal of medicinal chemistry, Vol. 66, Núm. 18, pp. 13043-13057
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Dissecting the interstrand crosslink DNA repair system of Trypanosoma cruzi
DNA Repair, Vol. 125
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Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen
Frontiers in Tropical Diseases, Vol. 4
2022
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Integrating information on the role of mosquitoes for the transmission of pathogens of wildlife
Ecology and Control of Vector-Borne Diseases, Vol. 7, pp. 249-253
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Introducing the role of mosquitoes in the transmission of pathogens to wildlife
Ecology and Control of Vector-Borne Diseases, Vol. 7, pp. 11-13
2021
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Bioluminescent:Fluorescent trypanosoma cruzi reporter strains as tools for exploring chagas disease pathogenesis and drug activity
Current Pharmaceutical Design, Vol. 27, Núm. 14, pp. 1733-1740
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Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease
European Journal of Medicinal Chemistry, Vol. 223
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Image-based in vitro screening reveals the trypanostatic activity of hydroxymethylnitrofurazone against trypanosoma cruzi
International Journal of Molecular Sciences, Vol. 22, Núm. 13
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Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale
PLoS Pathogens, Vol. 17, Núm. 8
2020
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Challenges in Chagas Disease Drug Development
Molecules, Vol. 25, Núm. 12
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Drug-cured experimental trypanosoma cruzi infections confer long-lasting and crossstrain protection
PLoS Neglected Tropical Diseases, Vol. 14, Núm. 4, pp. 1-20
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Intracellular dna replication and differentiation of trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection
PLoS Neglected Tropical Diseases, Vol. 14, Núm. 3
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Non-invasive monitoring of drug action: A new live in vitro assay design for chagas’ disease drug discovery
PLoS Neglected Tropical Diseases, Vol. 14, Núm. 7, pp. 1-17
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Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate: Trypanosoma cruzi proliferation
Open Biology, Vol. 10, Núm. 12
2019
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Exploiting genetically modified dual-reporter strains to monitor experimental trypanosoma cruzi infections and host-parasite interactions
Methods in Molecular Biology (Humana Press Inc.), pp. 147-163
2018
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Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping
PLoS Neglected Tropical Diseases, Vol. 12, Núm. 4
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Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation
Molecular and Biochemical Parasitology, Vol. 226, pp. 34-36