FACULTAD DE CIENCIAS
Facultad
Hospital Universitario de Canarias
San Cristóbal de La Laguna, EspañaPublicaciones en colaboración con investigadores/as de Hospital Universitario de Canarias (38)
2024
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Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine:glyoxylate aminotransferase variants
FEBS Letters, Vol. 598, Núm. 4, pp. 485-499
2023
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Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease-associated NQO1 enzyme*
FEBS Journal, Vol. 290, Núm. 7, pp. 1855-1873
2022
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Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity‐Making Mutations
Antioxidants, Vol. 11, Núm. 6
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Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations
Archives of Biochemistry and Biophysics, Vol. 729
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Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation
Frontiers in Molecular Biosciences, Vol. 9
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Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants
Molecules (Basel, Switzerland), Vol. 27, Núm. 24
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Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1
Journal of Personalized Medicine, Vol. 12, Núm. 5
2021
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SD-OCT peripapillary nerve fibre layer and ganglion cell complex parameters in glaucoma: Principal component analysis
British Journal of Ophthalmology, Vol. 105, Núm. 4, pp. 496-501
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Socio-Demographic Health Determinants Are Associated with Poor Prognosis in Spanish Patients Hospitalized with COVID-19
Journal of General Internal Medicine, Vol. 36, Núm. 12, pp. 3737-3742
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Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue
Redox Biology, Vol. 46
2020
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Daily changes in the expression of clock genes in sepsis and their relation with sepsis outcome and urinary excretion of 6-sulfatoximelatonin
Shock
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Naturally-occurring rare mutations cause mild to catastrophic effects in the multifunctional and cancer-associated NQO1 protein
Journal of Personalized Medicine, Vol. 10, Núm. 4, pp. 1-31
2019
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A dynamic core in human NQO1 controls the functional and stability effects of ligand binding and their communication across the enzyme dimer
Biomolecules, Vol. 9, Núm. 11
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GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
Nature Communications, Vol. 10, Núm. 1
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Identification of a 3′-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study
Arthritis and Rheumatology, Vol. 71, Núm. 3, pp. 351-360
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Insight into the specificity and severity of pathogenic mechanisms associated with missense mutations through experimental and structural perturbation analyses
Human Molecular Genetics, Vol. 28, Núm. 1, pp. 1-15
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Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I
Advances in Protein Chemistry and Structural Biology (Academic Press Inc.), pp. 119-152
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Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1
Nucleic Acid Therapeutics, Vol. 29, Núm. 2, pp. 104-113
2018
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A phase 2 trial of neoadjuvant metformin in combination with trastuzumab and chemotherapy in women with early HER2-positive breast cancer: The METTEN study
Oncotarget, Vol. 9, Núm. 86, pp. 35687-35704
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Evolutionary divergent suppressor mutations in conformational diseases
Genes, Vol. 9, Núm. 7