Capacidad antitumoral y quimiopreventiva del pinoresinol, principal lignano presente en los aceites de oliva vírgenes, evaluado en modelos celulares de mama humanos

Abstract

The scientific evidences correlate Virgin Olive Oil (VOO), major source of fat in the Mediterranean diet, with a low incidence of breast cancer. Due to its biological benefits, the phenol compounds found in VOOs are of great interest. One of the most abundant is (+)-pinoresinol, which also is a phytoestrogen with similar characteristics to human estrogens, often implicated in the development and progression of breast tumors. This study analyzes the chemopreventive and/or antitumor effects of (+)-pinoresinol in human breast cells. The results show that (+)-pinoresinol exerts cytotoxic, antiproliferative and prooxidant effects in human breast tumor cells with different estrogen receptors expression and malignancy (MDA-MB-231 and MCF7). On the other hand, (+)-pinoresinol acts as antioxidant and protector against oxidative DNA damage on human mammary epithelial cells (MCF10A) after oxidative injury