Analysis of extraskeletal function of vitamin d and cardiovascular risk factors in patients with psoriasis
- Orgaz Molina, Jacinto
- Salvador Arias Santiago Director
- Miguel Ángel Arrabal Polo Co-director
- Agustín Buendia Eisman Co-director
Defence university: Universidad de Granada
Fecha de defensa: 12 July 2013
- Salvio Serrano Ortega Chair
- Francisco Javier Gómez Jiménez Secretary
- Ricardo Juan Bosch García Committee member
- Americo Figueiredo Committee member
- Mercedes Zubiaur Marcos Committee member
Type: Thesis
Abstract
In recent years there has been described an increased prevalence of cardiovascular disease associated with increased mortality in patients with psoriasis. Psoriasis is a chronic inflammatory disease pathogenically characterized by an unbalanced immune expression in favor of a predominant Th1 response. Moreover, cardiovascular disease today is defined as a chronic inflammatory disease with pathogenic phenomena similar to those observed in plaque psoriasis. Moreover, a lower level of vitamin D has been described in connection with certain chronic inflammatory diseases, such as multiple sclerosis, lupus or rheumatoid arthritis. Also, it has been noted an inverse relationship between serum vitamin D and the prevalence and mortality associated with cardiovascular diseases. On this basis, we decided to conduct a study to compare cardiovascular risk factors (through assessment of the presence of MS and carotid atheroma) in psoriatic patients compared with a control group and evaluate this cardiovascular risk with clinical parameters of psoriasis and inflammatory parameters. Moreover, in the literature there is a lack of studies on vitamin D in patients with psoriasis and their relationship with cardiovascular risk. Therefore, we evaluated the serum concentration of vitamin D in patients with psoriasis compared with a control group and its relationship with SM and carotid atheromatosis.