Analysis of extraskeletal function of vitamin d and cardiovascular risk factors in patients with psoriasis

Laburpena

In recent years there has been described an increased prevalence of cardiovascular disease associated with increased mortality in patients with psoriasis. Psoriasis is a chronic inflammatory disease pathogenically characterized by an unbalanced immune expression in favor of a predominant Th1 response. Moreover, cardiovascular disease today is defined as a chronic inflammatory disease with pathogenic phenomena similar to those observed in plaque psoriasis. Moreover, a lower level of vitamin D has been described in connection with certain chronic inflammatory diseases, such as multiple sclerosis, lupus or rheumatoid arthritis. Also, it has been noted an inverse relationship between serum vitamin D and the prevalence and mortality associated with cardiovascular diseases. On this basis, we decided to conduct a study to compare cardiovascular risk factors (through assessment of the presence of MS and carotid atheroma) in psoriatic patients compared with a control group and evaluate this cardiovascular risk with clinical parameters of psoriasis and inflammatory parameters. Moreover, in the literature there is a lack of studies on vitamin D in patients with psoriasis and their relationship with cardiovascular risk. Therefore, we evaluated the serum concentration of vitamin D in patients with psoriasis compared with a control group and its relationship with SM and carotid atheromatosis.