Nanopartículas Magnéticas en el Diagnóstico y Tratamiento del Cáncer
- Doello, Kevin 1
- Cabeza, Laura 1
- Ortiz, Raul 2
- Arias, Jose Luis 1
- Melguizo, Consolación 1
- Prados, Jose 1
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1
Universidad de Granada
info
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2
Universidad de Jaén
info
ISSN: 0365-7965
Ano de publicación: 2015
Tomo: 100
Número: 796
Páxinas: 139-145
Tipo: Artigo
Outras publicacións en: Actualidad médica
Resumo
Los avances en el campo de la nanotecnología incluyen el desarrollo de nuevas nanopartículas que están siendo usadas en el en el campo de la oncología, no sólo como nuevos vehiculizadores de drogas capaces de dirigirlas a lugares específicos al mismo tiempo que disminuyen sus efectos sistémicos, sino como mediadores para generar calor localizado (hipertermia) como terapia antitumoral y para la localización y visualización de este tipo de patología. En este contexto, las nanopartículas que incorporan núcleos magnéticos confiriéndoles propiedades paramagnéticas están cobrando gran relevancia en el campo del diagnóstico tumoral y también en el del tratamiento ya sea sólo para aplicar la hipertermia o para combinarla con fenómenos de direccionamiento de drogas citotóxicas mediante la adición en la superficie de la nanopartícula de moléculas que reconocen algún tipo de biomarcador de cáncer (“targeting activo”). El principal objetivo de esta revisión es presentar los avances más relevantes en el desarrollo de nanoplataformas que incorporan núcleos magnéticos y que representan una nueva estrategia para el tratamiento y/o diagnóstico del cáncer (teragnosis) indicando los principales ensayos in vitro e in vivo y especialmente los ensayos clínicos más significativos que tiene como base esta nueva concepción terapéutica dentro del campo de la oncología.
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