Agrandamiento gingival por vigabatrina. Descripción clínica e histopatológica de un nuevo caso
- Mesa Aguado, FL
- López Leyva, C
- González Moles, MA
- Moral, RG del
- O'valle Ravassa, FJ
ISSN: 1137-2834
Year of publication: 2000
Volume: 5
Issue: 2
Pages: 133-137
Type: Article
More publications in: Medicina oral
Abstract
Gamma-vinyl GABA (vigabatrin, VGB) is a relatively recent drug prescribed to adolescents and adults with epileptic seizures refractory to conventional treatment. No type of oral disorder is mentioned among its adverse effects. However, a 29-year-old male treated during 5 years with VGB for partial epileptic seizures refractory to classic anticonvulsive treatment presented a moderate overgrowth of the free and attached gingiva. The present case is the first described in Spain, and the second in the world literature. We provide a clinical, histopathological and morphometric description of the gingival lesion. These data should be of value to the clinician for counseling patients on risks and for minimizing symptoms.