Does experienced pain affects local brain volumes? Insights from a clinical acute pain model

  1. Laura Torrecillas-Martínez 1
  2. Andrés Catena 2
  3. Francisco O'Valle 3
  4. Miguel Padial-Molina 4
  5. Pablo Galindo-Moreno 4
  1. 1 University of Pennsylvania
    info

    University of Pennsylvania

    Filadelfia, Estados Unidos

    ROR https://ror.org/00b30xv10

  2. 2 Universidad de Granada, Departamento de Psicología Experimental
  3. 3 Universidad de Granada, Departamento de Patología
  4. 4 Universidad de Granada, Departamento de Estomatología
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Revista:
International journal of clinical and health psychology

ISSN: 1697-2600

Año de publicación: 2019

Volumen: 19

Número: 2

Páginas: 115-123

Tipo: Artículo

DOI: 10.1016/J.IJCHP.2019.01.001 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: International journal of clinical and health psychology

Resumen

Antecedentes/Objetivo:Se trata de determinar la asociación entre dolor percibido y morfometría cerebral en tres etapas postquirúrgicas (anestesia, dolor y analgesia), en un modelo de dolor agudo. Método:Se obtuvo una imagen cerebral estructural de alta resolución y posteriormente se extrajeron los terceros molares mandibulares impactados. Se realizó un análisis morfométrico para determinar volumen cerebral y forma de núcleos subcorticales. Se realizaron análisis de regresión múltiple, siendo la intensidad del dolor el predictor, y el volumen y la forma de los núcleos subcorticales, medidos pre-cirugía, las variables dependientes. Resultados:El dolor experimentado fue mayor en la etapa de dolor que en las de anestesia y analgesia, y mayor en anestesia que en analgesia. El dolor se asoció con el volumen de materia gris en áreas corticales (insula, giros frontal medial y temporal, precuneus y cingulado anterior) y subcorticales (hipocampo, tálamo, putamen y amígdala). El número de áreas asociadas al dolor experimentado fue mayor en la etapa de dolor que en las de anestesia y analgesia. Conclusiones:La relación entre volumen cerebral regional y forma de núcleos subcorticales con la intensidad del dolor no es fijo, sino que varía en función de la etapa post-quirúrgica (magnitud del dolor).

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Información de financiación

This investigation was partially supported by Research Groups #CTS-138, #CTS-176 and #CTS-1028. ( Junta de Andalucía, Spain). LTM also was supported by the Talentia Scholarship Program of the Regional Ministry for Innovation, Science and Enterprise (Junta de Andalucía) and this research was conducted as part of her PDh project. The authors would like to thank to Unidad de Excelencia Salud, Comportamiento y Cerebro.

Financiadores

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Fuente de los datos: Dialnet