Publicaciones en colaboración con investigadores/as de Universidad de Zaragoza (17)

2024

  1. Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations

    Protein Science, Vol. 33, Núm. 4

2023

  1. Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease-associated NQO1 enzyme*

    FEBS Journal, Vol. 290, Núm. 7, pp. 1855-1873

2022

  1. A single evolutionarily divergent mutation determines the different FAD-binding affinities of human and rat NQO1 due to site-specific phosphorylation

    FEBS Letters, Vol. 596, Núm. 1, pp. 29-41

  2. Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity‐Making Mutations

    Antioxidants, Vol. 11, Núm. 6

  3. Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations

    Archives of Biochemistry and Biophysics, Vol. 729

  4. Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants

    Molecules (Basel, Switzerland), Vol. 27, Núm. 24

  5. Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1

    Journal of Personalized Medicine, Vol. 12, Núm. 5

2021

  1. Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1

    International Journal of Biological Macromolecules, Vol. 170, pp. 549-560

  2. Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue

    Redox Biology, Vol. 46

2020

  1. The catalytic cycle of the antioxidant and cancer-associated human NQO1 enzyme: Hydride transfer, conformational dynamics and functional cooperativity

    Antioxidants, Vol. 9, Núm. 9, pp. 1-22

2019

  1. Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability

    International Journal of Biological Macromolecules, Vol. 125, pp. 1275-1288

2017

  1. Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

    Human Molecular Genetics, Vol. 26, Núm. 18, pp. 3531-3544

  2. Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of polycomb RING1B

    Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Núm. 31, pp. E6332-E6341

  3. Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

    Scientific Reports, Vol. 7

  4. Thermodynamics of cooperative binding of FAD to human NQO1: Implications to understanding cofactor-dependent function and stability of the flavoproteome

    Archives of Biochemistry and Biophysics, Vol. 636, pp. 17-27

2016

  1. The chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from marine bacterium Vibrio sp FC509 is a dimeric species: Biophysical characterization of an endosulfatase

    Biochimie, Vol. 131, pp. 85-95

2008

  1. Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria

    Journal of Clinical Investigation, Vol. 118, Núm. 8, pp. 2858-2867