ENRIQUE JOSÉ
COBOS DEL MORAL
CATEDRÁTICO DE UNIVERSIDAD
RAFAEL
GONZÁLEZ CANO
PROF. AYUDANTE DOCTOR
Publicaciones en las que colabora con RAFAEL GONZÁLEZ CANO (20)
2023
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Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity
Journal of Medicinal Chemistry, Vol. 66, Núm. 16, pp. 11447-11463
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Minocycline Prevents the Development of Key Features of Inflammation and Pain in DSS-induced Colitis in Mice
Journal of Pain, Vol. 24, Núm. 2, pp. 304-319
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Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands
ACS Chemical Neuroscience, Vol. 14, Núm. 10, pp. 1845-1858
2022
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Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation
European Journal of Medicinal Chemistry, Vol. 230
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Soluble Epoxide Hydrolase Inhibitors: Design, Synthesis, in vitro Profiling and in vivo Evaluation in Murine Models of Pain
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 36
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Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors
Journal of medicinal chemistry, Vol. 65, Núm. 20, pp. 13660-13680
2021
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Sigma-1 receptor: A drug target for the modulation of neuroimmune and neuroglial interactions during chronic pain
Pharmacological Research, Vol. 163
2020
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El receptor sigma-1: una diana farmacológica que modula las interacciones neuroinmunitarias y neurogliales durante el dolor crónico
Actualidad en farmacología y terapéutica, Vol. 18, Núm. 3, pp. 173-186
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Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors
Frontiers in Pharmacology, Vol. 11
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The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?
Neuroscience and Biobehavioral Reviews, Vol. 113, pp. 238-261
2018
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Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling
Cell Reports, Vol. 22, Núm. 5, pp. 1301-1312
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Modality-specific peripheral antinociceptive effects of μ-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors
Neuropharmacology, Vol. 135, pp. 328-342
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Targeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists
Pharmacological Research, Vol. 131, pp. 224-230
2017
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Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States
Journal of Pain, Vol. 18, Núm. 6, pp. 716-725
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Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Núm. 31, pp. 8396-8401
2016
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Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin
Scientific Reports, Vol. 6
2014
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Modulation of peripheral μ-opioid analgesia by σ1 receptors
Journal of Pharmacology and Experimental Therapeutics, Vol. 348, Núm. 1, pp. 32-45
2013
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El receptor Sigma (s 1): Un freno biológico a la analgesia opioide periférica
Actualidad en farmacología y terapéutica, Vol. 11, Núm. 4, pp. 282-284
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Potentiation of morphine-induced mechanical antinociception by σ1 receptor inhibition: Role of peripheral σ1 receptors
Neuropharmacology, Vol. 70, pp. 348-358
2012
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Tetrodotoxin (TTX) as a therapeutic agent for pain
Marine Drugs, Vol. 10, Núm. 2, pp. 281-305