LUISA CARLOTA
LÓPEZ CARA
PROFESORA TITULAR DE UNIVERSIDAD
University of Ferrara
Ferrara, ItaliaPublicaciones en colaboración con investigadores/as de University of Ferrara (46)
2019
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Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
Journal of Medicinal Chemistry, Vol. 62, Núm. 3, pp. 1274-1290
2018
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2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition
European Journal of Medicinal Chemistry, Vol. 143, pp. 683-698
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Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 33, Núm. 1, pp. 727-742
2017
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Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents
European Journal of Medicinal Chemistry, Vol. 134, pp. 258-270
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Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents
Scientific Reports, Vol. 7
2016
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Design and synthesis of potent in vitro and in vivo anticancer agents based on 1-(3',4',5'-trimethoxyphenyl)-2-Aryl-1H-imidazole
Scientific Reports, Vol. 6
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Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation
European Journal of Medicinal Chemistry, Vol. 108, pp. 39-52
2015
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Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin
Journal of Medicinal Chemistry, Vol. 58, Núm. 7, pp. 3209-3222
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Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study
European Journal of Medicinal Chemistry, Vol. 101, pp. 185-204
2014
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Design, synthesis and biological evaluation of 3,5-disubstituted 2-amino thiophene derivatives as a novel class of antitumor agents
Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 18, pp. 5097-5109
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Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5- substituted thiophene derivatives as allosteric enhancers of the A1 adenosine receptor
Bioorganic and Medicinal Chemistry, Vol. 22, Núm. 1, pp. 148-166
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Synthesis and biological evaluation of novel allosteric enhancers of the A1adenosine receptor based on 2-amino-3-(4′-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene
Journal of Medicinal Chemistry, Vol. 57, Núm. 18, pp. 7673-7686
2013
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Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[ b ]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents
Journal of Medicinal Chemistry, Vol. 56, Núm. 22, pp. 9296-9309
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Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4- substituted thiophenes as allosteric enhancers of the A1 adenosine receptor
European Journal of Medicinal Chemistry, Vol. 67, pp. 409-427
2012
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Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1- yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A 1 adenosine receptor
Bioorganic and Medicinal Chemistry, Vol. 20, Núm. 2, pp. 996-1007
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Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4- arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor
Journal of Medicinal Chemistry, Vol. 55, Núm. 17, pp. 7719-7735
2011
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One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5- (3′,4′,5′-trimethoxybenzoyl)thiazole: A unique, highly active antimicrotubule agent
European Journal of Medicinal Chemistry, Vol. 46, Núm. 12, pp. 6015-6024
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Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3',4',5'-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis
ChemMedChem, Vol. 6, Núm. 10, pp. 1841-1853
2010
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Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation
Bioorganic and Medicinal Chemistry Letters, Vol. 20, Núm. 9, pp. 2733-2739
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Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues
Journal of Medicinal Chemistry, Vol. 53, Núm. 10, pp. 4248-4258