Novel strategies for the treatment of visceral pain. Role of voltage-gated sodium channels and enhancement of the opioid-induced analgesia by selective blockade of sigma-1 receptor

  1. Artacho Cordón, Antonia
Zuzendaria:
  1. Cruz Miguel Cendán Martínez Zuzendaria

Defentsa unibertsitatea: Universidad de Granada

Fecha de defensa: 2022(e)ko apirila-(a)k 05

Epaimahaia:
  1. José Manuel Baeyens Cabrera Presidentea
  2. Enrique José Cobos del Moral Idazkaria
  3. Lydia Jiménez Díaz Kidea
  4. Carolina Laura Roza Fernández de Caleya Kidea
  5. Enrique Portillo Salido Kidea
Saila:
  1. FARMACOLOGÍA

Mota: Tesia

Laburpena

The first goal of this Thesis was to evaluate the antinociceptive effects of TTXin three different visceral pain models in mice: the intracolonic administration of both capsaicin and mustard oil; and a model of cyclophosphamideinduced cystitis.